If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. It is important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects. Blood and urine tests may be needed to check for any unwanted effects. Do not start taking desvenlafaxine within 14 days after you stop using an MAO inhibitor.
Wait 7 days after stopping desvenlafaxine before you start taking an MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or bowel symptoms, a sudden high body temperature, an extremely high blood pressure, or severe seizures. Desvenlafaxine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors.
It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder manic-depressive or has tried to commit suicide. Do not stop using this medicine without first checking with your doctor.
Your doctor may want you to gradually reduce the amount you are taking before stopping it completely to decrease the chance of side effects, such as agitation, breathing problems, chest pain, confusion, diarrhea, dizziness or lightheadedness, fast heartbeat, headache, increased sweating, muscle pain, nausea, restlessness, runny nose, trouble with sleeping, trembling or shaking, unusual tiredness or weakness, vision changes, or vomiting.
Desvenlafaxine may cause a serious condition called serotonin syndrome if taken together with some medicines. Check with your doctor first before using any other medicines with desvenlafaxine. Tell your doctor right away if you have chest discomfort, cough, or trouble breathing while using this medicine. Two other studies looked at people with fibromyalgia.
Stopping Pristiq suddenly can cause withdrawal symptoms. Doing so will help you avoid withdrawal symptoms. Drinking alcohol can increase your risk for having side effects from Pristiq. These side effects include:.
Drinking alcohol can also make your depression symptoms worse. Other drugs are available that can treat major depressive disorder. Some may be better suited for you than others. Other SNRIs and drugs from other classes of medications are also available to treat depression. They can tell you about other medications that may work well for you. You may wonder how Pristiq compares to other medications that are prescribed for similar uses. Here we look at how Pristiq and Effexor XR are alike and different.
Pristiq contains desvenlafaxine, while Effexor XR contains venlafaxine. Both drugs belong to a class of antidepressants called serotonin-norepinephrine reuptake inhibitors SNRIs. A class of medications is a group of drugs that work in a similar way in your body. Desvenlafaxine and venlafaxine are closely related. Venlafaxine the drug in Effexor XR is metabolized broken down by your liver.
Desvenlafaxine is known as an active metabolite of venlafaxine. When you take venlafaxine, most of the antidepressant effect in your body is actually produced by desvenlafaxine. MDD is often called depression. Pristiq is taken by mouth once daily. It should be swallowed whole, and it can be taken with or without food. Effexor XR comes as extended-release capsules.
Effexor XR is taken by mouth once each day. Effexor XR capsules can be swallowed whole. Or the capsules can be opened and sprinkled onto a spoonful of applesauce. The applesauce should then be swallowed without chewing, followed by drinking a glass of water to make sure the drug is completely swallowed. With either option, Effexor XR should be taken with food. Pristiq and Effexor XR are closely related. Therefore, both medications can cause very similar side effects.
Below are examples of these side effects. One review of clinical studies found that, in general, these two drugs had similar effectiveness for treating depression. Pristiq and Effexor XR are both brand-name drugs. There are generic forms of both drugs available. Brand-name medications usually cost more than generics. According to estimates on GoodRx. Here we look at how Pristiq and Cymbalta are alike and different.
Pristiq contains desvenlafaxine, while Cymbalta contains duloxetine. Pristiq is taken by mouth each day. It can be taken with or without food. Cymbalta comes as delayed-release capsules. Cymbalta capsules are typically taken once or twice a day. They can be taken with or without food. Pristiq and Cymbalta are both from the same class of drugs.
These lists contain examples of serious side effects that can occur with Pristiq, with Cymbalta, or with both drugs when taken individually.
But separate studies have found both Pristiq and Cymbalta to be effective for treating depression. Pristiq and Cymbalta are both brand-name drugs. There generic forms of both drugs available. You can also call the American Association of Poison Control Centers at or use their online tool. But if your symptoms are severe, call or go to the nearest emergency room right away. Pristiq can interact with several other medications.
It can also interact with certain supplements. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Below are lists of medications that can interact with Pristiq. These lists do not contain all the drugs that may interact with Pristiq.
Before taking Pristiq, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Taking Pristiq with these drugs increases your risk of a serious side effect called serotonin syndrome.
This is a dangerous condition caused by high levels of a brain chemical called serotonin in your body. Pristiq, linezolid, and methylene blue can all raise your level of serotonin. When these drugs are taken together, your level of serotonin may be raised even higher.
Your doctor will monitor you closely for signs of serotonin syndrome. You can start taking Pristiq again 24 hours after your last dose of linezolid or methylene blue. Taking Pristiq with a monoamine oxidase inhibitor MAOI increases your risk of a serious side effect called serotonin syndrome. This is a dangerous condition caused by having high levels of a brain chemical called serotonin in your body. MAOIs are a class of antidepressants. A class of drugs is a group of medications that act in a similar way.
MAOIs and Pristiq both increase levels of serotonin in your body. Taking Pristiq with certain other antidepressants can increase your risk of serotonin syndrome. Pristiq and certain other antidepressants all work by raising your levels of serotonin. Examples of other antidepressants that can increase your risk of serotonin syndrome if taken with Pristiq include the following.
Taking Pristiq with lithium Lithobid can increase your risk of serotonin syndrome. This is a dangerous condition that results when levels of a brain chemical called serotonin get too high in your body. Pristiq and lithium both increase your levels of serotonin. They may recommend different treatment options for you. Taking Pristiq with buspirone can increase your risk of serotonin syndrome.
This is a dangerous condition that results from high levels of a brain chemical called serotonin inside your body. Both Pristiq and buspirone can increase your levels of serotonin. They may recommend that you take a different drug to treat your anxiety. Taking triptan medications with Pristiq could increase your risk of a serious side effect called serotonin syndrome. This is a dangerous condition that occurs when levels of a brain chemical called serotonin get too high in your body.
Triptan medications and Pristiq both increase your levels of serotonin. Triptan medications are used to treat migraine and cluster headaches. Examples of triptan medications that increase your risk for serotonin syndrome if taken with Pristiq include:.
They may recommend that you take a different drug to treat your headaches. Taking tramadol ConZip, Ultram or fentanyl Duragesic, Subsys, Actiq, others with Pristiq increases your risk of serious side effect called serotonin syndrome. Should I take Pristiq morning or night? Does pristiq make you angry? Can pristiq make you gain weight? Is pristiq bad for your liver?
Which antidepressant is best for anxiety? What drug makes you feel the happiest? What vitamins help with depression? Which fruit is good for depression? If you miss a dose of desvenlafaxine take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your health care provider.
Do not double your next dose or take more than what is prescribed. Avoid drinking alcohol or using illegal drugs while you are taking antidepressant medications. They may decrease the benefits e. If an overdose occurs, call your doctor or You may need urgent medical care.
You may also contact the poison control center at Headache, nausea, vomiting, diarrhea, constipation, dry mouth, increased sweating, decreased appetite, tremor, feeling nervous, restless, fatigue, or having trouble sleeping insomnia. These will often improve over the first week or two as you continue to take the medication.
Sexual side effects, such as problems with orgasm or ejaculatory delay, and blood pressure increases often do not improve over time. Increased heart rate, low blood pressure, increased salivation, irregular menstrual cycle, increased frequency of urination, changes in taste, increased liver enzymes, low sodium symptoms of low sodium levels may include headache, weakness, difficulty concentrating and remembering , teeth grinding, difficulty urinating, angle closure glaucoma symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye , serotonin syndrome symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death , hypertensive crisis severely elevated blood pressure , myocardial infarction heart attack , Stevens-Johnson syndrome rash.
To date, there are no known problems associated with long term use of desvenlafaxine. It is a safe and effective medication when used as directed. Desvenlafaxine should not be taken with or within 2 weeks of taking monoamine oxidase inhibitors MAOIs.
Desvenlafaxine may increase the effects of other medications that can cause bleeding e. Sleep, energy, or appetite may show some improvement within the first weeks. Improvement in these physical symptoms can be an important early signal that the medication is working.
Depressed mood and lack of interest in activities may need up to weeks to fully improve. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. This risk may persist until significant remission occurs. In short-term studies, antidepressants increased the risk of suicidality in children, adolescents, and young adults when compared to placebo. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age
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